This course introduces the broad concepts of biomedical imaging across a range of modalities. It provides a foundation towards the understanding of how modern biomedical imaging technologies generate multi-dimensional data for analysis and diagnosis. Key technologies covered include: XRay, CT, MRI, FMRI, Ultrasound, light microscopy, and medical imaging processing. Application of the biomedical images used to interpret biological process and diagnostics disease will also be discussed in small groups. Hands-on practical laboratory visits to cutting edge advanced bioimaging systems will be available to reinforce the lecture material, and quantitative imaging processing in the context of basic research and clinical settings will be covered.

Learning Outcomes

Upon successful completion, students will have the knowledge and skills to:

1. Evaluate the operation and function of different biomedical imaging instruments on molecules, cells and organs.
2. Describe the principles of advanced biomedical imaging concepts and their application in health sciences.
3. Analyse the limitation of each biomedical imaging modalities and also how they complement each other for molecular, cellular and organ-level systems.
4. Apply advanced image processing to quantify biomedical images and critique the factors that contribute to analysis.
5. Understand and analyse major biomedical imaging modalities used in health sciences and outline their therapeutic aims.
6. Evaluate the research methods and outcomes from selected scientific publications related to the course curriculum.

Research-Led Teaching

Students will be introduced to advanced imaging processing and instruments developed at the John Curtin School of Medical Research. Students will be provided with opportunities to review leading research articles (peer review) in medical imaging and provide critical assessment of each imaging method.

Recommended Resources

• Biomedical Imaging: Principles and Applications Reiner Salzer (Editor)

Staff Feedback

Students will be given feedback in the following forms in this course:

• Written comments
• Verbal comments
• Feedback to the whole class, to groups, to individuals, focus groups

Student Feedback

ANU is committed to the demonstration of educational excellence and regularly seeks feedback from students. Students are encouraged to offer feedback directly to their Course Convener or through their College and Course representatives (if applicable). The feedback given in these surveys is anonymous and provides the Colleges, University Education Committee and Academic Board with opportunities to recognise excellent teaching, and opportunities for improvement. The Surveys and Evaluation website provides more information on student surveys at ANU and reports on the feedback provided on ANU courses.

Class Schedule

Week/Session	Summary of Activities	Assessment
1	Modern Medical Imaging Tutorial
2	Imaging through tissue I : High Energy Tutorial	Tutorial 1, Image Analysis 1 (X-Ray)
3	Imaging through tissue II : Magnet Tutorial	Tutorial 2, Image Analysis 2 (MRI)
4	Imaging through tissue III : Sounds, Light	Tutorial 3, Image Analysis 3 (Ultrasounds)
5	Cellular Imaging with light	Tutorial 4, Image Analysis 4 (Fluorescence)
6	Molecular Imaging	Tutorial 5, Image Analysis 5 (Endoscopy)
7	Machine Learning in Medical Imaging	Tutorial 6, Image Analysis 6 (Machine learning)
8	Revision 1
9	Laboratory Visit	Quiz (not graded)
10	Review of Image Analysis Tools
11	Group presentation A with peer review Grading	Group presentation, Group Report
12	Revision 2
13	Examination period	Final exam

Assessment Summary

Assessment task	Value	Due Date	Return of assessment	Learning Outcomes
Tutorial Quiz (written submission) and Image Analysis Class	15 %	*	*	1, 2, 3, 4.
Group Presentation	25 %	17/10/2022	04/11/2022	1, 2, 6.
Group Report	25 %	17/10/2022	04/11/2022	1, 2, 6.
Written Exam	35 %	*	*	1, 2, 3, 4, 5.

* If the Due Date and Return of Assessment date are blank, see the Assessment Tab for specific Assessment Task details

Policies

ANU has educational policies, procedures and guidelines, which are designed to ensure that staff and students are aware of the University’s academic standards, and implement them. Students are expected to have read the Academic Misconduct Rule before the commencement of their course. Other key policies and guidelines include:

• Student Assessment (Coursework) Policy and Procedure
• Special Assessment Consideration Policy and General Information
• Student Surveys and Evaluations
• Deferred Examinations
• Student Complaint Resolution Policy and Procedure

Assessment Requirements

The ANU is using Turnitin to enhance student citation and referencing techniques, and to assess assignment submissions as a component of the University's approach to managing Academic Integrity. For additional information regarding Turnitin please visit the ANU Online website Students may choose not to submit assessment items through Turnitin. In this instance you will be required to submit, alongside the assessment item itself, hard copies of all references included in the assessment item.

Moderation of Assessment

Marks that are allocated during Semester are to be considered provisional until formalised by the College examiners meeting at the end of each Semester. If appropriate, some moderation of marks might be applied prior to final results being released.

Assessment Task 1

Tutorial Quiz (written submission) and Image Analysis Class

Responses to Weekly session: (1) Answering Tutorial questions (10%, (2) Participate in Image Analysis Class (5%)

Due: Weeks 2-7

Value: 15%

Due date: 7 days after the tutorial is posted.

Assessment to be returned: 5 days after tutorial submission ended.

Assessment (Tutorial): Short qualitative answers on the application of each imaging modality. A sample question will be like

" A 5 year old boy fell through a window pane with 5 mm thick metal mesh and glass. He suffered a deep cut on his arm with pieces of metal and glass lodged deep into his humerus. Which object will show up with higher contrast in an X Ray Scan and Why? (2 marks)"

Assessment (Image Analysis) Students will be given image analysis projects related to "de-noising", "image averaging", "image segmentation", "thresholding", "object counting" using the ImageJ (NIH) software suite.

Assessment Task 2

Group Presentation

OUTLINE

• Group members are meant to review the selected paper.
• Presentation (15 minutes, 15 min Q&A)

Due date: Week 11. 17th Oct

Return date: 4th November

Value: 25%

The goal of the presentation is to convey the advantages of a given imaging modality for a disease versus others.

1) Disease focused Imaging

2) Overview of existing technology

3) Working Principles

4) Cost Benefit Analysis

5) Examples of successes

6) Future Technological developments for the disease diagnosis

Rubric

Able to articulate the role of technology	Verbal explanation of imaging techniques	practical overview of the benefits & disadvantages	Present logical technical roadmap for the diseases

Assessment Task 3

Group Report

OUTLINE

• Group members are meant to review the selected paper.
• Student will distribute their report into sections

Due date: Week 11. 17th Oct

Return date: 4th November

Value: 25%

Goal for the team here is to survey the latest/emerging technologies for a particular disease.

Example Topic 1: Optical Coherence Tomography (OCT) for Cardiovascular Diseases

1. Who developed and is currently advancing OCT

2. What are the challenges in introduction to OCT in Cardiovascular Diseases

3. What are the working principles and How are OCT images processed?

4. How OCT enables new findings in Cardiovascular Diseases

5. What Next Generation OCT in intravascular diagnosis

6. How does OCT Compare with other Cardiovascular Diseases

Rubric

Ability to explain the concepts	Illustrate logical analysis of the techniques	pros and cons of the techniques	insights onto the techniques presented	reach logical and meaningful conclusion.

Assessment Task 4

Written Exam

1 written exam (2.5 hrs) in the university examination period.

Value: 35%

Assessment will take the form of short answer written answers on how to practically apply the imaging technologies.

Example of a sub-question

"Recent research is indicating that patients with severe COVID-19 infection appear to be at greater risk of developing blood clots in veins and arteries, which is particularly dangerous for hospitalized patients. Describe the sequence of major events/phases that occur as blood clots around an injured site and why a COVID-19 blood clot can be detected through imaging. Identify an imaging tool that is best suited to detect blood clots in arteries instead of veins and explain why."

Academic Integrity

Academic integrity is a core part of our culture as a community of scholars. At its heart, academic integrity is about behaving ethically. This means that all members of the community commit to honest and responsible scholarly practice and to upholding these values with respect and fairness. The Australian National University commits to embedding the values of academic integrity in our teaching and learning. We ensure that all members of our community understand how to engage in academic work in ways that are consistent with, and actively support academic integrity. The ANU expects staff and students to uphold high standards of academic integrity and act ethically and honestly, to ensure the quality and value of the qualification that you will graduate with. The University has policies and procedures in place to promote academic integrity and manage academic misconduct. Visit the following Academic honesty & plagiarism website for more information about academic integrity and what the ANU considers academic misconduct. The ANU offers a number of services to assist students with their assignments, examinations, and other learning activities. The Academic Skills and Learning Centre offers a number of workshops and seminars that you may find useful for your studies.

Online Submission

The ANU uses Turnitin to enhance student citation and referencing techniques, and to assess assignment submissions as a component of the University's approach to managing Academic Integrity. While the use of Turnitin is not mandatory, the ANU highly recommends Turnitin is used by both teaching staff and students. For additional information regarding Turnitin please visit the ANU Online website.

Hardcopy Submission

For some forms of assessment (hand written assignments, art works, laboratory notes, etc.) hard copy submission is appropriate when approved by the Associate Dean (Education). Hard copy submissions must utilise the Assignment Cover Sheet. Please keep a copy of tasks completed for your records.

Late Submission

Late submission of assessment tasks without an extension are penalised at the rate of 5% of the possible marks available per working day or part thereof. Late submission of assessment tasks is not accepted after 10 working days after the due date, or on or after the date specified in the course outline for the return of the assessment item. Late submission is not accepted for take-home examinations.

Referencing Requirements

Accepted academic practice for referencing sources that you use in presentations can be found via the links on the Wattle site, under the file named “ANU and College Policies, Program Information, Student Support Services and Assessment”. Alternatively, you can seek help through the Students Learning Development website.

Returning Assignments

Assignments are returned on wattle to individual students.

Extensions and Penalties

Extensions and late submission of assessment pieces are covered by the Student Assessment (Coursework) Policy and Procedure The Course Convener may grant extensions for assessment pieces that are not examinations or take-home examinations. If you need an extension, you must request an extension in writing on or before the due date. If you have documented and appropriate medical evidence that demonstrates you were not able to request an extension on or before the due date, you may be able to request it after the due date.

Resubmission of Assignments

There are no resubmission of Assignments

Privacy Notice

The ANU has made a number of third party, online, databases available for students to use. Use of each online database is conditional on student end users first agreeing to the database licensor’s terms of service and/or privacy policy. Students should read these carefully. In some cases student end users will be required to register an account with the database licensor and submit personal information, including their: first name; last name; ANU email address; and other information. In cases where student end users are asked to submit ‘content’ to a database, such as an assignment or short answers, the database licensor may only use the student’s ‘content’ in accordance with the terms of service — including any (copyright) licence the student grants to the database licensor. Any personal information or content a student submits may be stored by the licensor, potentially offshore, and will be used to process the database service in accordance with the licensors terms of service and/or privacy policy. If any student chooses not to agree to the database licensor’s terms of service or privacy policy, the student will not be able to access and use the database. In these circumstances students should contact their lecturer to enquire about alternative arrangements that are available.

Distribution of grades policy

Academic Quality Assurance Committee monitors the performance of students, including attrition, further study and employment rates and grade distribution, and College reports on quality assurance processes for assessment activities, including alignment with national and international disciplinary and interdisciplinary standards, as well as qualification type learning outcomes. Since first semester 1994, ANU uses a grading scale for all courses. This grading scale is used by all academic areas of the University.

Support for students

The University offers students support through several different services. You may contact the services listed below directly or seek advice from your Course Convener, Student Administrators, or your College and Course representatives (if applicable).

• ANU Health, safety & wellbeing for medical services, counselling, mental health and spiritual support
• ANU Diversity and inclusion for students with a disability or ongoing or chronic illness
• ANU Dean of Students for confidential, impartial advice and help to resolve problems between students and the academic or administrative areas of the University
• ANU Academic Skills and Learning Centre supports you make your own decisions about how you learn and manage your workload.
• ANU Counselling Centre promotes, supports and enhances mental health and wellbeing within the University student community.
• ANUSA supports and represents undergraduate and ANU College students
• PARSA supports and represents postgraduate and research students